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[66] has demonstrated that bacteria may directly cause epigenetic alterations in the host, as indicated by distinct patterns of DNA modification in immature intestinal epithelial cells after exposure to commensal or pathogenic pathogens

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Glutathione S -transferase P1 (GSTP1), the gene encoding the pi-class GST, is frequently inactivated by acquired somatic CpG island promoter hypermethylation in multiple cancer subtypes including prostate, breast, liver, and blood cancers